[ Pobierz całość w formacie PDF ]
17. Ionescu RM, Vlasak J, Price C, Kirchmeier M. 2008. 652 663.
Contribution of variable domains to the stability of 29. Van Buren N, Rehder D, Gadgil H, Matsumura M,
humanized IgG1 monoclonal antibodies. J Pharm Jacob J. 2009. Elucidation of two major aggregation
Sci 97:1414 1426. pathways in an IgG2 antibody. J Pharm Sci
18. Pantoliano MW, Petrella EC, Kwasnoski JD, Loba- 98:3013 3030.
nov VS, Myslik J, Graf E, Carver T, Asel E, Springer 30. Kameoka D, Masuzaki E, Ueda T, Imoto T. 2007.
BA, Lane P, Salemme FR. 2001. High-density min- Effect of buffer species on the unfolding and the
iaturized thermal shift assays as a general strategy aggregation of humanized IgG. J Biochem 142:383
for drug discovery. J Biomol Screen 6:429 440. 391.
19. Lavinder JJ, Hari SB, Sullivan BJ, Magliery TJ. 31. Vermeer AW, Norde W. 2000. The thermal stability
2009. High-throughput thermal scanning: A gen- of immunoglobulin: Unfolding and aggregation of a
eral, rapid dye-binding thermal shift screen for multi-domain protein. Biophys J 78:394 404.
protein engineering. J Am Chem Soc 131:3794 32. Patro SY, Przybycien TM. 1996. Simulations of
3795. reversible protein aggregate and crystal structure.
20. Niesen FH, Berglund H, Vedadi M. 2007. The use of Biophys J 70:2888 2902.
differential scanning fluorimetry to detect ligand 33. Vermeer AW, Norde W, van Amerongen A. 2000.
interactions that promote protein stability. Nat The unfolding/denaturation of immunogammaglo-
Protoc 2:2212 2221. bulin of isotype 2b and its F(ab) and F(c) fragments.
21. Ericsson UB, Hallberg BM, Detitta GT, Dekker Biophys J 79:2150 2154.
N, Nordlund P. 2006. Thermofluor-based high- 34. Arakawa T, Timasheff SN. 1985. The stabilization
throughput stability optimization of proteins for of proteins by osmolytes. Biophys J 47:411 414.
structural studies. Anal Biochem 357:289 298. 35. Tian F, Middaugh CR, Offerdahl T, Munson E, Sane
22. Malawski GA, Hillig RC, Monteclaro F, Eberspae- S, Rytting JH. 2007. Spectroscopic evaluation of the
cher U, Schmitz AA, Crusius K, Huber M, Egner U, stabilization of humanized monoclonal antibodies
Donner P, Muller-Tiemann B. 2006. Identifying in amino acid formulations. Int J Pharm 335:20
protein construct variants with increased crystal- 31.
lization propensity a case study. Protein Sci 15: 36. Jones LS, Randolph TW, Kohnert U, Papadimitriou
2718 2728. A, Winter G, Hagmann ML, Manning MC,
23. Vedadi M, Niesen FH, Allali-Hassani A, Fedorov Carpenter JF. 2001. The effects of Tween 20 and
OY, Finerty PJ, Jr., Wasney GA, Yeung R, Arrow- sucrose on the stability of anti-L-selectin during
smith C, Ball LJ, Berglund H, Hui R, Marsden BD, lyophilization and reconstitution. J Pharm Sci 90:
Nordlund P, Sundstrom M, Weigelt J, Edwards AM. 1466 1477.
2006. Chemical screening methods to identify 37. Esfandiary R, Kickhoefer VA, Rome LH, Joshi SB,
ligands that promote protein stability, protein crys- Middaugh CR. 2009. Structural stability of vault
tallization, and structure determination. Proc Natl particles. J Pharm Sci 98:1376 1386.
Acad Sci USA 103:15835 15840. 38. Andya JD, Hsu CC, Shire SJ. 2003. Mechanisms of
24. Lo MC, Aulabaugh A, Jin G, Cowling R, Bard J, aggregate formation and carbohydrate excipient
Malamas M, Ellestad G. 2004. Evaluation of fluor- stabilization of lyophilized humanized monoclonal
escence-based thermal shift assays for hit identifi- antibody formulations. AAPS PharmSci 5:E10.
DOI 10.1002/jps JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 99, NO. 4, APRIL 2010
1720 HE ET AL.
39. Chang LL, Shepherd D, Sun J, Ouellette D, 42. Treuheit MJ, Kosky AA, Brems DN. 2002. Inverse
Grant KL, Tang XC, Pikal MJ. 2005. Mechanism relationship of protein concentration and aggrega-
of protein stabilization by sugars during freeze- tion. Pharm Res 19:511 516.
drying and storage: Native structure preserva- 43. Gokarn YR, Fesinmeyer RM, Saluja A, Cao S,
tion, specific interaction, and/or immobilization Dankberg J, Goetze A, Remmele RL, Jr., Narhi
in a glassy matrix? J Pharm Sci 94:1427 LO, Brems DN. 2009. Ion-specific modulation of
1444. protein interactions: Anion-induced, reversible oli-
[ Pobierz całość w formacie PDF ]